Unfortunately there is still no software application that can handle your emails.

I’ve seen some interesting prototypes but still nothing usable.
Maybe one day, a Gmail 2.0 add-on will read your email, move unwanted messages to your “not now” folder, schedule meetings in your calendar if the sender invites you to one, and highlight emails from your wife (or maybe mark them as spam ).

Until then, an interesting alternative is ActiveInbox: GTD based work-flow add-on for Gmail which lets you “handle email as a flow of actions”, as the developers say.

Its main objective is to make the zero inbox rule a reality.
This rule is part of the GTD process by David Allen, which illustrates how to bring to zero your inbox and file all your messages in the right place.

With ActiveInbox you can better focus on high priority emails, track emails that you are waiting for a reply to, file emails into projects for easy retrieval. All this with user-friendly dropdown menus right into your Gmail account.
With a simple to use add-on for Gmail you will see an extra menu on your left column, showing contexts, projects and ToDos. With one click you can see all your emails to a given person from which you are expeting a reply. Or you can check, project by project, which are your next actions.

ActiveInbox comes with a free version and a premium account for $24.95/year.